In Vitro, In Vivo and Phytochemical Screening, of Extracts of Piper guineense for trypanocidal Activities Against Trypanosoma brucei brucei.
Bibliographic record
Abstract
Extracts from leaves and stem bark of Piper guineense were evaluated for trypanocidal activity against Trypanosoma brucei brucei in vitro and in vivo. The phytochemical screening of the most active extracts in vitro was carried out. The Petroleum ether extract of stem bark exhibited highest in vitro trypanocidal activity out of the six extracts tested. Thus it was used to treat animals infected with Trypanosoma brucei brucei at a dose range of 50-200 mg/kg body weight, intraperitoneally and orally. The results showed that the group treated with 100 mg/kg body weight intraperitoneally showed significant reduction in parasiteamia with a prolonged life span up to the 18th day post infection. While those that were treated with 200 mg/kg body weight orally, had progressive increase in parasiteamia up to the 7th and 8th day post infection when they all died. However in the prophylactic experiment animals that were treated with 50 mg/kg intraperitoneally and 100 mg/kg orally for five days before challenging them with 103 trypanosomes, did not develop parasiteamia up to 28th day post infection when the experiment was terminated. This experiment shows that the petroleum ether of Piper guineense possesses some degree of trypanocidal activity and further purification of the active component should be carried out.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".