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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

2010· article· en· 1,183 citations· W2129032286 on OpenAlex· 10.1038/nature09582

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.004
GPT teacher head0.205
Teacher spread
0.202 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature
Topic
Genetics and Neurodevelopmental Disorders
Field
Biochemistry, Genetics and Molecular Biology
Canadian institutions
Ontario GenomicsUniversity of Ottawa
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentU.S. Public Health ServiceNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthHoward Hughes Medical Institute
Keywords
MECP2Rett syndromeGABAergicNeuroscienceGlutamate decarboxylaseAutismForebrainNeuroliginNeurodevelopmental disorderPhenotypeBiologyPsychologyGeneticsInhibitory postsynaptic potentialExcitatory postsynaptic potentialGenePsychiatryCentral nervous systemBiochemistry
Has abstract in OpenAlex
no