Cardiac Troponin T Is Not Detected in Western Blots of Diseased Renal Tissue
Bibliographic record
Abstract
Recent publications of consensus documents for the redefinition of myocardial infarction are heavily predicated on the role of increases in cardiac troponin (I or T) in serum in the setting of ischemic symptoms (1)(2)(3)). Cardiac troponin T (cTnT) has also been reported to be a predictor of mortality in patients with end stage renal disease (4)(5). An unexplained increase in the frequency of increased serum cTnT compared with serum cardiac troponin I has been described in these patients (6)(7). Explanations advanced for this difference include the possibility of nonspecific reactions in the cTnT assay or de novo expression of cTnT in skeletal muscle of renal diseased patients that is subsequently released into the serum (8). However, recent studies on skeletal muscle from renal disease patients have shown that although the two antibodies used in the cTnT diagnostic assay (M7 and M11.7) individually bind to muscle proteins, this would not cause false-positive results in the current-generation cTnT assay marketed by Roche (8). On the other hand, cardiac troponin I is not expressed in fetal or in healthy or diseased adult human skeletal tissue (9). An additional possibility is that cTnT or other immunoreactive proteins are being expressed in diseased renal tissue. In the current …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".