Chemical Eluates from Ultra-High Molecular Weight Polyethylene and Fibroblast Proliferation
Bibliographic record
Abstract
Although polyethylene wear particles have been implicated in osteolysis and implant loosening, this study is the first to test whether chemical eluates extracted from ultra-high molecular weight polyethylene (UHMWPE) could also be involved in this process. Eluates were prepared from UHMWPE bar stock and examined for their effects on (3)H-thymidine incorporation by human foreskin fibroblasts grown in 96-well culture plates. Low concentrations of eluates stimulated (3)H-thymidine uptake; whereas, high concentrations inhibited uptake in a dose-dependent manner. Maximum inhibition of proliferation for eluates (87+/-0.03% inhibition, n = 45 paired wells) was greater than that observed for particles (54+/-0.07% inhibition, n = 45 paired wells). Ethylene oxide sterilization of UHMWPE reduced (3)H-thymidine uptake at low eluate concentrations relative to sterilization by gamma-irradiation. It was concluded that leachable eluates from UHMWPE implantse contribute to the osteolytic process at the bone-implant interface.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".