Surface Plasmon Resonance Determination of the Binding Mechanisms of <scp>l</scp>-Cysteine and Mercaptoundecanoic Acid on Gold
Bibliographic record
Abstract
Surface plasmon resonance was used for the real-time monitoring of the formation of self-assembled monolayers of l -cysteine and 11-mercaptoundecanoic acid (MUA) on gold surfaces. We provide comparative details on the kinetics of the assembly of short thiols with multiple functional groups, as opposed to longer alkanethiols with fewer functional groups. Our results indicate that the adsorption of l -cysteine is a rapid process, involving both amino- and thiol-Au interactions, followed by the exchange of amino-Au to thiol-Au species and the physisorption of a second cysteine layer. The formation of MUA is also rapid, followed by a slower structural rearrangement of the monolayer. We find that monolayer formation, for both l -cysteine and MUA, is described by the Langmuir isotherm at low concentrations only. Numerical models are introduced to describe the assembly of both higher and lower concentrations of thiolated molecules on gold.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".