The Inhibitory Control of Oocyte Maturation in the Zebrafish (Danio rerio): The Role of the G Protein-Coupled Estrogen Receptor and Epidermal Growth Factor
Bibliographic record
Abstract
The development and maturation of oocytes in fish have been studied extensively [1, 2]. The complex and coordinated actions of pituitary gonadotropins, ovarian-derived growth factors, and sex steroids occur in concert to ensure the ovulation and spawning of hundreds of viable oocytes from fish ovaries. It is well established that steroid hormones, notably estrogens and progestins, are involved with oocyte growth and resumption of meiosis, respectively. The ovarian follicle produces large amounts of 17β-estradiol (E2) to support the synthesis of vitellogenin by the liver; this protein is sequestered by the growing oocytes. During this period of growth, the oocytes are arrested at the first meiotic prophase by high intracellular levels of cAMP. Intraoocyte levels of cAMP decline when gonadotropin (luteinizing hormone) levels surge during the periovulatory period, leading to the increased synthesis of a maturation-inducing steroid (MIS; e.g., 17α,20β-dihydroxy-4-pregnen-3-one and related progestins) that induces final maturation of the oocyte via nongenomic actions involving a membrane progesterone receptor [3].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.006 | 0.005 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".