Poxvirus Immunomodulatory Strategies: Current Perspectives
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Successful transmission by viruses in the face of vigorous innate and acquired host immunity requires the ability to evade, obstruct, or subvert critical elements that mediate host antiviral responses. To that end, viruses with larger genomes, such as poxviruses, encode multiple classes of immunomodulatory proteins that have evolved specifically to inhibit such diverse processes as apoptosis, the production of interferons, chemokines, and inflammatory cytokines, and the activity of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, complement, and antibodies. Often, the evolutionary origins of these virus-encoded immunomodulatory proteins are difficult to trace. The obvious sequence similarity between some immunomodulatory poxvirus genes and the cDNA versions of related cellular counterparts suggests that they were once captured by ancestral retrotranscription and/or recombination events and then reassorted into individual virus isolates during coevolution with vertebrate hosts. However, other poxviral immunomodulators have no known cellular counterpart or have putative functions that cannot be predicted based on similarity to known cellular proteins. The origins of these orphan regulators may be obscure, but their potential for immune subversion can be profound.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it