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Record W2132439215 · doi:10.1002/hipo.20313

Posterior parahippocampal place learning in H.M.

2007· article· en· W2132439215 on OpenAlexaff
Véronique D. Bohbot, Suzanne Corkin

Bibliographic record

VenueHippocampus · 2007
Typearticle
Languageen
FieldNeuroscience
TopicMemory and Neural Mechanisms
Canadian institutionsMcGill UniversityDouglas Mental Health University Institute
FundersNational Institute on Aging
KeywordsCortex (anatomy)Task (project management)NeurosciencePsychologyHippocampusMorris water navigation task

Abstract

fetched live from OpenAlex

In a previous experiment with patients who had undergone unilateral temporal thermocoagulation lesions to alleviate intractable epilepsy, we demonstrated that the right parahippocampal cortex was critical for the performance of a spatial memory task (Bohbot et al. (1998) Neuropsychologia 36:1217-1238). Based on this evidence, we predicted that H.M., whose caudal parahippocampal cortex was structurally intact (Corkin et al. (1997) J Neurosci 17:3964-3979), would be able to learn the spatial memory task. This task was designed to be a human analogue of the Morris water maze in that it measured participants' ability to learn the location of a target, which was an invisible weight sensor placed under a carpet (Bohbot et al. (1998) Neuropsychologia 36:1217-1238). H.M. was first tested with the sensor under a small carpet (162 cm x 150 cm). Then, interspersed with the first sensor location, he was tested with the sensor in a second location, covered by a larger carpet (250 cm x 210 cm). He found the second target location in a direct path on only 10% of the trials. In contrast, when tested on the first sensor location, he walked directly toward the center of the testing area in 19/35 trials and from there found the sensor in a direct path on 15 of the 19 trials (80%). The number of direct hits at the first target location was significantly greater than chance (P < 0.0005). An analysis of H.M.'s paths showed that they were characteristic of fast learning, and that he did not rely on egocentric, short-term, or working memory strategies to learn the task. H.M's ability to locate the sensor is remarkable given his severe amnesia and his inability to explicitly recollect the testing episode. These findings underscore the role of the parahippocampal cortex in spatial memory.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.043
Threshold uncertainty score0.739

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.051
GPT teacher head0.309
Teacher spread0.258 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations75
Published2007
Admission routes1
Has abstractyes

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