Ibuprofen was more effective than codeine or acetaminophen for musculoskeletal pain in children
Bibliographic record
Abstract
Clark E, Plint AC, Correll R, et al . A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Pediatrics 2007;119:460–7. [OpenUrl][1][Abstract/FREE Full Text][2] Q In children with musculoskeletal pain, what is the relative efficacy of ibuprofen, acetaminophen, and codeine? Clinical impact ratings Paediatrics ★★★★★★★ Emergency medicine ★★★★★★☆ Paediatric emergency medicine ★★★★★☆☆ ### ![Graphic][3]</img>Design: randomised controlled trial. ### ![Graphic][4]</img>Allocation: {concealed}*.† ### ![Graphic][5]</img>Blinding: blinded (patients [children and parents], {healthcare providers}*, and data collectors).† ### ![Graphic][6]</img>Follow up period: 120 minutes. ### ![Graphic][7]</img>Setting: the emergency department of an academic, tertiary care children’s hospital in Ottawa, Ontario, Canada. ### ![Graphic][8]</img>Patients: 336 children 6–17 years of age (mean age 12 y, 60% boys) presenting to the emergency department with pain from a musculoskeletal injury to extremities, neck, or back that occurred in the previous 48 hours. Exclusion criteria included contraindication to a study drug, receipt of 1 of the study drugs in … [1]: {openurl}?query=rft.jtitle%253DPediatrics%26rft.stitle%253DPediatrics%26rft.issn%253D0031-4005%26rft.aulast%253DClark%26rft.auinit1%253DE.%26rft.volume%253D119%26rft.issue%253D3%26rft.spage%253D460%26rft.epage%253D467%26rft.atitle%253DA%2BRandomized%252C%2BControlled%2BTrial%2Bof%2BAcetaminophen%252C%2BIbuprofen%252C%2Band%2BCodeine%2Bfor%2BAcute%2BPain%2BRelief%2Bin%2BChildren%2BWith%2BMusculoskeletal%2BTrauma%26rft_id%253Dinfo%253Adoi%252F10.1542%252Fpeds.2006-1347%26rft_id%253Dinfo%253Apmid%252F17332198%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=pediatrics&resid=119/3/460&atom=%2Febmed%2F12%2F5%2F144.atom [3]: /embed/inline-graphic-1.gif [4]: /embed/inline-graphic-2.gif [5]: /embed/inline-graphic-3.gif [6]: /embed/inline-graphic-4.gif [7]: /embed/inline-graphic-5.gif [8]: /embed/inline-graphic-6.gif
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How this classification was reachedexpand
Direct model labels (unvalidated)
Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.
| Model arm | Categories | Study design | Confidence |
|---|---|---|---|
| gemma | no category Domain: not available · Genre: Other About the Canadian research system: no · About a Canadian topic: no | Not applicable | low |
| gpt | no category Domain: not available · Genre: Commentary About the Canadian research system: no · About a Canadian topic: no | Randomized trial | low |
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.010 | 0.014 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedLabeled directly by 2 models reading the full record.
The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".