Regulation of Global Gene Expression by Ovariectomy and Estrogen in Female Adipose Tissue
Why this work is in the frame
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Bibliographic record
Abstract
OBJECTIVE: To study the effects of ovariectomy (OVX) and estrogen replacement on global gene expression in white adipose tissue. RESEARCH METHODS AND PROCEDURES: Female mice were randomly divided into four groups: 1) intact, 2) OVX, 3) OVX plus estradiol (E2) injection 3 hours before death (E(2)-3 hours), and 4) E(2)-24 hours. The serial analysis of gene expression was performed to detect the transcriptomic changes. RESULTS: A total of 15 transcripts, including several novel transcripts, were found to be modulated by OVX or E2 (p<0.05). Secreted acidic cysteine-rich glycoprotein, which regulates the extracellular matrix (ECM) components, was increased after OVX. Moreover, OVX up-regulated several transcripts involved in ECM, such as procollagen types Ialpha1 and 2. In cell defense, glutathione peroxidase 3 was lower in OVX than in intact mice. Cytochrome c oxidase I and three novel transcripts were up-regulated by estrogen treatment. DISCUSSION: This study underlines the importance of cell shape and ECM regulation by OVX on adiposity. Moreover, some novel transcripts may also play a relevant role in OVX-induced obesity and estrogen therapy.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it