Occurrence of Buffalo Hump and Laryngeal Cancer in a HIV-1 Infected Patient with Metabolic Disorders Receiving a Rescue HAART Regimen
Bibliographic record
Abstract
Reported cases of laryngeal squamous cell carcinomas are rare in HIV-1 infected patients. We describe a 68 year-old heavy smoker HIV -1 positive male receiving a salvage combination antiretroviral therapy, who developed a differentiated laryngeal cancer staging T3N0Mx after a 21 year history of HIV-1 infection. The patient also presented a severe fat redistribution with “buffalo hump” accompanied by subcutaneous adipose tissue lipoatrophy at arms and legs, and a dis-metabolic syndrome. Head and neck movements were severely limited by this voluminous mass. The presence of immune-suppression at the diagnosis with a relatively low grade staging of the neoplasm determined the choice of a combined chemo-radiation therapy, taking also in account the high infective risk linked to the surgery approach compared to that of acute toxicity reactions. A two years disease free follow up reinforced the needs of an early and accurate screening for neoplasms in HIV-1 infected patients. doi:10.4021/jm c 569w
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".