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Record W2135176038 · doi:10.1038/ng.2408

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus

2012· article· en· W2135176038 on OpenAlexaff
Zhan Su, Laura J. Gay, Amy Strange, Claire Palles, Gavin Band, David C. Whiteman, Francesco Lescai, Cordelia Langford, Manoj Nanji, Sarah Edkins, Anouk van der Winkel, David Levine, Peter Sasieni, Céline Bellenguez, Kimberley Howarth, Colin Freeman, Nigel Trudgill, Art Tucker, Matti Pirinen, Maikel P. Peppelenbosch, Luc J. W. van der Laan, Ernst J. Kuipers, Joost P.H. Drenth, Wilbert H.M. Peters, John V. Reynolds, Dermot Kelleher, Ross McManus, Heike I. Grabsch, Hans Prenen, Raf Bisschops, Kausila Krishnadath, Peter D. Siersema, Jantine W.P.M. van Baal, Mark R. Middleton, Russell Petty, Richard Gillies, Nicola Burch, Pradeep Bhandari, Stuart Paterson, Cathryn Edwards, Ian Penman, Kishor Vaidya, Yeng Ang, Iain Murray, Praful Patel, Weimin Ye, Paul D. Mullins, Anna H. Wu, Nigel C. Bird, Helen Dallal, Nicholas J. Shaheen, Liam Murray, Konrad Koss, Leslie Bernstein, Yvonne Romero, Laura J. Hardie, Rui Zhang, Helen Winter, Douglas A. Corley, Simon Panter, Harvey A. Risch, Brian J. Reid, Ian Sargeant, Marilie D. Gammon, Howard Smart, Anjan Dhar, Hugh McMurtry, Haythem Ali, Geoffrey Liu, Alan G. Casson, Wong‐Ho Chow, Matt Rutter, Ashref Tawil, Danielle Morris, Chuka Nwokolo, Peter Isaacs, Colin Rodgers, Krish Ragunath, Chris MacDonald, Chris Haigh, David Gabriel Monk, Gareth Davies, Saj Wajed, David Johnston, Michael Gibbons, Sue Cullen, Nicholas Church, Ruth E. Langley, S M Griffin, Derek Alderson, Panos Deloukas, Sarah Hunt, Emma Gray, Serge Dronov, Simon Potter, Avazeh Tashakkori-Ghanbaria, Mark Anderson, Claire Brooks, Jenefer M. Blackwell, Elvira Bramon, Matthew A. Brown, Juan P. Casas, Aiden Corvin, Audrey Duncanson, Hugh S. Markus, Christopher G. Mathew, Robert Plomin, Anna Rautanen, Stephen Sawcer, Richard C. Trembath, Ananth C. Viswanathan, Nicholas Wood, Gosia Trynka, Cisca Wijmenga, Jean‐Baptiste Cazier, Paul Atherfold, Anna M. Nicholson, Nichola Gellatly, Deborah Glancy, Sheldon C. Cooper, David Cunningham, Tore Lind, Julie Hapeshi, David Ferry, B J Rathbone, Julia Brown, Sharon Love, Stephen Attwood, Stuart MacGregor, Peter J. Watson, S. Sanders, Weronica E. Ek, Rebecca Harrison, Paul Moayyedi, John de Caestecker, Hugh Barr, Elia Stupka, Thomas L. Vaughan, Leena Peltonen, Chris C. A. Spencer, Ian Tomlinson, Peter Donnelly, Janusz Jankowski

Bibliographic record

VenueNature Genetics · 2012
Typearticle
Languageen
FieldMedicine
TopicEsophageal Cancer Research and Treatment
Canadian institutionsUniversity of SaskatchewanPrincess Margaret Cancer CentreUniversity of TorontoMcMaster University Medical CentreUniversity Health Network
FundersNational Cancer InstituteNational Institute for Health and Care ResearchCancer Research UKWellcome Trust
KeywordsBiologyLocus (genetics)GeneticsBarrett's esophagusEsophagusMajor histocompatibility complexGeneAnatomy

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.310
Teacher spread0.297 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations170
Published2012
Admission routes1
Has abstractno

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