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Record W2135481547 · doi:10.1093/aje/kwt201

Welding and Lung Cancer in a Pooled Analysis of Case-Control Studies

2013· article· en· W2135481547 on OpenAlexaffabout
Benjamin Kendzia, Thomas Behrens, Karl‐Heinz Jöckel, Jack Siemiatycki, Hans Kromhout, Roel Vermeulen, Susan Peters, Rainer Van Gelder, Ann Olsson, Irene Brüske, H-Erich Wichmann, Isabelle Stücker, Florence Guida, Adonina Tardón, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Hermann Pohlabeln, Wolfgang Ahrens, Maria Teresa Landi, Neil E. Caporaso, Dario Consonni, David Zaridze, Neonila Szeszenia‐Dąbrowska, Jolanta Lissowska, Per Gustavsson, Michael W. Marcus, Eleonóra Fabiánová, Andrea ’t Mannetje, Neil Pearce, Lap Ah Tse, I. Yu, Péter Rudnai, Vladimír Bencko, Vladimí­r Janout, Dana Mateș, Lenka Foretová, Francesco Forastiere, Paul A. Demers, Bas Bueno‐de‐Mesquita, Paolo Boffetta, Joachim Schüz, Kurt Straíf, Beate Pesch, Thomas Brüning

Bibliographic record

VenueAmerican Journal of Epidemiology · 2013
Typearticle
Languageen
FieldMedicine
TopicOccupational exposure and asthma
Canadian institutionsOccupational Cancer Research CentreUniversité de Montréal
FundersNational Institute on Drug Abuse
KeywordsOdds ratioLung cancerConfidence intervalMedicineRisk factorCase-control studyInternal medicineCancerSurgery

Abstract

fetched live from OpenAlex

Several epidemiologic studies have indicated an increased risk of lung cancer among welders. We used the SYNERGY project database to assess welding as a risk factor for developing lung cancer. The database includes data on 15,483 male lung cancer cases and 18,388 male controls from 16 studies in Europe, Canada, China, and New Zealand conducted between 1985 and 2010. Odds ratios and 95% confidence intervals between regular or occasional welding and lung cancer were estimated, with adjustment for smoking, age, study center, and employment in other occupations associated with lung cancer risk. Overall, 568 cases and 427 controls had ever worked as welders and had an odds ratio of developing lung cancer of 1.44 (95% confidence interval: 1.25, 1.67) with the odds ratio increasing for longer duration of welding. In never and light smokers, the odds ratio was 1.96 (95% confidence interval: 1.37, 2.79). The odds ratios were somewhat higher for squamous and small cell lung cancers than for adenocarcinoma. Another 1,994 cases and 1,930 controls had ever worked in occupations with occasional welding. Work in any of these occupations was associated with some elevation of risk, though not as much as observed in regular welders. Our findings lend further support to the hypothesis that welding is associated with an increased risk of lung cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.026
Threshold uncertainty score0.254

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.388
Teacher spread0.361 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations64
Published2013
Admission routes2
Has abstractyes

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