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Record W2135514753 · doi:10.1038/cdd.2009.44

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

2009· review· en· W2135514753 on OpenAlexaff
Lorenzo Galluzzi, Stuart A. Aaronson, John Abrams, Emad S. Alnemri, David W. Andrews, Eric H. Baehrecke, Nicolás G. Bazán, Mikhail V. Blagosklonny, Klas Blomgren, Christoph Borner, Dale E. Bredesen, Catherine Brenner, Maria Castedo, John A. Cidlowski, Aaron Ciechanover, Gerald M. Cohen, Vincenzo De Laurenzi, Ruggero De Maria, Mohanish Deshmukh, Brian David Dynlacht, Wafik S. El‐Deiry, Richard A. Flavell, Simone Fulda, Carmen Garrido, Pierre Golstein, D. R. Green, Hinrich Gronemeyer, G. Hajnóczky, J. Marie Hardwick, Michael O. Hengartner, Hidenori Ichijo, Marja Jäättelä, Oliver Kepp, Adi Kimchi, Daniel J. Klionsky, Richard A. Knight, Sally Kornbluth, Sharad Kumar, Beth Levine, Stuart A. Lipton, Enrico Lugli, Frank Madeo, Walter Malorni, Séamus J. Martin, Jan Paul Medema, Patrick Mehlen, Gerry Melino, Ute M. Moll, Eugenia Morselli, Shigekazu Nagata, D. W. Nicholson, Pierluigi Nicotera, Gabriel Núñez, Moshe Oren, Josef Penninger, Shazib Pervaiz, Marcus E. Peter, Mauro Piacentini, Jochen H.M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Rosario Rizzuto, Cecília M. P. Rodrigues, David C. Rubinsztein, Thomas Rudel, Luca Scorrano, Hermann Steller, J Tschopp, Yoshihide Tsujimoto, Peter Vandenabeele, Ilio Vitale, Karen H. Vousden, Richard J. Youle, Junying Yuan, Boris Zhivotovsky, Guido Kroemer

Bibliographic record

VenueCell Death and Differentiation · 2009
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCell death mechanisms and regulation
Canadian institutionsMcMaster University
FundersNational Institute of Neurological Disorders and StrokeNational Institute of General Medical SciencesMedical Research CouncilWellcome TrustAgence Nationale de la RechercheStyrelsen för Internationellt UtvecklingssamarbeteNational Health and Medical Research CouncilSidactionEuropean CommissionNational Cancer InstituteNational Institutes of HealthInstitut National Du Cancer
KeywordsProgrammed cell deathBiologyNecroptosisDemiseInterpretation (philosophy)ApoptosisComputational biologyComputer scienceGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.006
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.004
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0060.005
Science and technology studies0.0010.002
Scholarly communication0.0020.002
Open science0.0060.002
Research integrity0.0050.005
Insufficient payload (model declined to judge)0.0060.013

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.106
GPT teacher head0.331
Teacher spread0.225 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations680
Published2009
Admission routes1
Has abstractno

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