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Record W2136558851 · doi:10.1038/ng.567

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

2010· review· en· W2136558851 on OpenAlexfundno aff
Rachel M. Freathy, Dennis O. Mook‐Kanamori, Ulla Sovio, Inga Prokopenko, Nicholas J. Timpson, Diane J. Berry, Nicole M. Warrington, Elisabeth Widén, Jouke Jan Hottenga, Marika Kaakinen, Leslie A. Lange, Jonathan P. Bradfield, Marjan Kerkhof, Julie Marsh, Reedik Mägi, Chih‐Mei Chen, Helen N. Lyon, Mirna Kirin, Linda S. Adair, Yurii S. Aulchenko, Amanda J. Bennett, Judith B. Borja, Nabila Bouatia‐Naji, Pimphen Charoen, Lachlan Coin, Diana L. Cousminer, Eco J. C. de Geus, Panos Deloukas, Paul Elliott, David M. Evans, Philippe Froguel, Beate Glaser, Christopher J. Groves, Anna‐Liisa Hartikainen, Neelam Hassanali, Joel N. Hirschhorn, Albert Hofman, Jeff M.P. Holly, Elina Hyppönen, Stavroula Kanoni, Bridget Knight, Jaana Laitinen, Cecilia M. Lindgren, Wendy L. McArdle, Paul F. O’Reilly, Craig E. Pennell, Dirkje S. Postma, Anneli Pouta, Adaikalavan Ramasamy, Nigel W. Rayner, Susan M. Ring, Fernando Rivadeneira, Beverley M. Shields, David P. Strachan, Ida Surakka, Anja Taanila, Carla M. T. Tiesler, André G. Uitterlinden, Cornelia M. van Duijn, Alet H. Wijga, Gonneke Willemsen, Haitao Zhang, Jianhua Zhao, James F. Wilson, Eric A.P. Steegers, Andrew T. Hattersley, Johan G. Eriksson, Leena Peltonen, Karen L. Mohlke, Struan F.A. Grant, Håkon Håkonarson, Gerard H. Koppelman, George Dedoussis, Joachim Heinrich, Matthew W. Gillman, Lyle J. Palmer, Timothy M. Frayling, Dorret I. Boomsma, George Davey Smith, Chris Power, Vincent W. V. Jaddoe, Marjo‐Riitta Järvelin

Bibliographic record

VenueNature Genetics · 2010
Typereview
Languageen
FieldMedicine
TopicBirth, Development, and Health
Canadian institutionsnot available
FundersNational Institute of Environmental Health SciencesNational Center for Research ResourcesNational Institute of Allergy and Infectious DiseasesNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney DiseasesBiocenter, University of OuluMünchner Zentrum für Gesundheitswissenschaften, Ludwig-Maximilians-Universität MünchenMedical Research CouncilNational Institutes of HealthErasmus Universiteit RotterdamEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentZonMwRaine Medical Research FoundationBritish Heart FoundationScottish GovernmentHealthwayErasmus Medisch CentrumUniversity of BristolOulun YliopistoEuropean CommissionFogarty International CenterJuvenile Diabetes Research Foundation InternationalDiabetes UKCanadian Institutes of Health ResearchRoyal SocietyBundesministerium für Bildung und ForschungNational Institute for Health and Care ResearchNational Health and Medical Research CouncilChildren's Hospital of PhiladelphiaNederlandse Organisatie voor Wetenschappelijk OnderzoekWellcome Trust
KeywordsBirth weightBiologyGenome-wide association studySingle-nucleotide polymorphismLow birth weightPregnancyGenetic associationGeneticsAlleleDemographyGeneGenotype

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.003
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0010.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.294
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations258
Published2010
Admission routes1
Has abstractno

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