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Record W2138103041 · doi:10.18632/aging.100132

Impact papers on aging in 2009

2010· review· en· W2138103041 on OpenAlex
Mikhail V. Blagosklonny, J. Campisi, David Sinclair, Andrzej Bartke, Marı́a A. Blasco, William M. Bonner, Vilhelm A. Bohr, Robert M. Brosh, Anne Brunet, Ronald A. DePinho, Lawrence A. Donehower, Caleb E. Finch, Toren Finkel, Myriam Gorospe, Andrei V. Gudkov, Michael N. Hall, Siegfried Hekimi, Stephen L. Helfand, Jan Karlseder, Cynthia Kenyon, Guido Kroemer, Valter D. Longo, André Nussenzweig, Heinz D. Osiewacz, Daniel S. Peeper, Thomas A. Rando, K. Lenhard Rudolph, Paolo Sassone‐Corsi, Manuel Serrano, Norman E. Sharpless, Vladimir P. Skulachev, Jonathan L. Tilly, John Tower, Eric Verdin, Jan Vijg

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueAging · 2010
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsMcGill University
FundersNational Cancer InstituteNational Institute on Aging
KeywordsArt historyArtPhilosophyHumanitiesEnvironmental ethics

Abstract

fetched live from OpenAlex

The Editorial Board of Aging reviews research papers published in 2009, which they believe have or will have significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechanisms of life span extension by calorie restriction and pharmacological interventions into aging. The emerging message in 2009 is that aging is not random but determined by a genetically-regulated longevity network and can be decelerated both genetically and pharmacologically.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.996
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.326
Teacher spread0.305 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it