Associations Between Liver Function, Bone Turnover Biomarkers and Adipokines in Older Patients With Hip Fracture
Bibliographic record
Abstract
Background: To examine the associations of serum liver markers with parameters of mineral and bone metabolism and their relationship with leptin, adiponectin and resistin in patients with hip fracture (HF). Methods: In 294 older patients (mean age 82.2 ± 7.9 years, 72.1% women) with osteoporotic HF, we measured serum levels of alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), bilirubin, albumin, adiponectin, leptin, resistin, 25(OH) vitamin D (25(OH)D), intact parathyroid hormone (PTH), calcium, phosphate, magnesium, osteocalcin (OC), bone-specific alkaline phosphatase (BAP), urinary concentrations of deoxypyridinoline (DPD/Cr) and cross-linked N-telopeptide of type 1 collagen (NTx/Cr) (both corrected for urinary creatinine concentrations), as well as routine blood parameters. Results: In the total cohort, in fully adjusted multivariate linear regression analyses, lower OC was an independent predictor of higher GGT, ALT and bilirubin, whereas higher BAP was positively associated with GGT and ALP; NTx/Cr, hemoglobin (both inversely), adiponectin, coronary artery disease (CAD) and alcohol overuse (all three positively) were also independently associated with GGT activity. However, in malnourished women, OC was not an independent predictor of GGT or ALT and NTx/Cr predicted ALP activity. OC was independently predicted by GGT, ALT (both negatively), ALP, leptin and age (all three positively), BAP by GGT and ALP, OC/BAP ratio by GGT (inversely) and leptin (positively) and both elevated NTx/Cr and DPD/Cr by higher ALP and lower leptin levels. The GGT > 20 U/L indicated increased prevalence of low OC levels (two-fold) and low OC/BAP ratio (2.6-fold) with a positive predictive value above 75%. Conclusions: In older HF patients, bidirectional links exist between liver function (within normal range in the vast majority) and parameters of bone metabolism. Adiponectin is an independent predictor of GGT, whereas leptin is a determinant of OC and bone resorption; these relationships are modulated by nutritional status. GGT > 20 U/L may be used as a marker of impaired bone metabolism. J Endocrinol Metab. 2014;4(5-6):121-135 doi: http://dx.doi.org/10.14740/jem250w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".