Angiotensin II Inhibits Cell Proliferation and Stimulates Protein Synthesis in Rat Glomerulosa Cells
Bibliographic record
Abstract
Angiotensin II (Ang Il) is one of the most important stimuli of rat adrenaI glomerulosa cells. The aim of the present study was to investigate whether Ang Il can stimulate cell proliferation and/or hypertrophy and to investigate pathways of these two specific growth responses. Results reveal that a 3-day treatment with Ang Il abolished cell proliferation observed in control cells, but increased protein synthesis. Preincubation with PD98059 (a MEK inhibitor) diminished basal proliferation and affected basal protein synthesis. In contrast, the p38 MAPK inhibitor, SB203580, reversed the inhibitory effect on cell proliferation and abolished the increase in protein synthesis, although the JNK inhibitor had no effect. Time-course studies indeed indicate that Ang II stimulates phosphorylation of p42/p44 mapk (peak at 5 min with a sustained plateau) and of p38 mapk (rapid and transient effect at 2 min), but did not activate JNK. Preincubation with cytochalasin B abolished basal proliferation. Immunofluorescence studies indicate that Ang II favored the formation of a peripheral cortical actin ring, but a depolymerization of the cross-linked F-actin network. Together, these results indicate that a well-developed network of microfilaments is necessary to promote basal cell proliferation, while microfilament disruption are involved in Ang II
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".