Cell-compatible hydrogels based on a multifunctional crosslinker with tunable stiffness for tissue engineering
Bibliographic record
Abstract
This paper reports a functionalized cationic poly(amidoamine) crosslinker synthesized by Michael addition of peptide mimetic agmatine to N,N′-bis(acryloyl)cystamine. A polyethylene glycol diacrylate (PEGDA) hybrid hydrogel was developed using a functionalized crosslinker with cell adhesion capability and tunable stiffness. This engineered hydrogel presents a 3-D in-growth of cells and the cryosection shows remarkable morphology of the gel. The tunable stiffness of this hydrogel can regulate the osteogenic differentiation of mesenchymal stem cells from RT-PCR. Both in vitro and in vivo tests demonstrate adjustable degradation rate and biocompatibility. The crosslinker and its hydrogels hold promising potential for tissue engineering applications.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".