Residual renal function after partial or radical nephrectomy for renal cell carcinoma
Bibliographic record
Abstract
Renal cell carcinoma (RCC) is often detected incidentally andearly. Currently, open partial nephrectomy and laparoscopic totalnephrectomy form competing technologies. The former is invasive,but nephron-sparing; the other is considered less invasive but withmore loss of renal mass. Traditionally, emphasis has been placedon oncologic outcomes. However, a patient with an excellentoncologic outcome may suffer from morbidity and mortality relatedto renal failure. Animal models with hypertension and diabeticrenal disease indicate accelerated progression of pre-existing diseaseafter nephrectomy. Patients with RCC are older and they havea high prevalence of diabetes and hypertension. The progressionof renal failure may also be accelerated after a nephrectomy. Ouranalysis of the available literature indicates that renal outcomes inRCC patients after surgery are relatively poorly defined. A strategyto systematically evaluate the renal function of patients with RCC,with joint discussion between the nephrologist and the oncologicteam, is strongly advocated.L’hypernéphrome est souvent décelé fortuitement et au stade précoce.Actuellement, la néphrectomie partielle par voie ouverteet la néphrectomie totale par laparoscopie sont des technologiesconcurrentes. Tandis que la première est plus invasive, mais permetl’épargne des néphrons, la seconde est moins invasive maisentraîne une perte plus importante de masse rénale. Par le passé,on a mis l’emphase sur les résultats d’un point de vue oncologique.Cependant, un patient pour qui la chirurgie donne d’excellents résultatsen matière d’élimination de la tumeur pourrait présenter unemorbidité et une mortalité en lien avec une insuffisance rénale. Desmodèles animaux de néphropathie avec hypertension et diabèteindiquent une évolution accélérée des maladies préexistantes aprèsla néphrectomie. Les patients présentant un hypernéphrome sontplus âgés; la prévalence du diabète et de l’hypertension est élevée.L’évolution de l’insuffisance rénale peut aussi être accélérée aprèsla néphrectomie. Notre analyse des articles publiés montre que lesrésultats sur le plan de la fonction rénale après une chirurgie pourtraiter un hypernéphrome sont relativement mal définis. Une stratégiefondée sur une évaluation systématique de la fonction rénale despatients atteints d’hypernéphrome, avec discussion entre le néphrologueet l’équipe de soins oncologiques, est fortement encouragée.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".