Paclitaxel in Combination with Coumarin as a Potentially Effective Anticancer Agent
Bibliographic record
Abstract
The antimitotic and clastogenic effects induced by paclitaxel alone, and when combined with coumarin at varying concentrations and volume ratios, were investigated on meristematic cells of Allium sativum L. root tips. Paclitaxel exhibited antimitotic effects by blocking cell division in metaphase at concentrations ranging from saturated to 10 -12 ppm. Paclitaxel when used alone at high concentrations (saturated, 10 -3 ppm, 10 -6 ppm) induced cytotoxic and chromosomal aberrations after 1 and 3 h incubation and cell death after 24 h incubation. Paclitaxel demonstrated fewer cytotoxic and clastogenic effects when combined with coumarin in a 1:9 ratio at low concentrations. The combination of 10 -12 ppm of paclitaxel with 200 ppm coumarin (1:9) produced the best results as these agents worked together synergistically at the biochemical level to produce antimitotic effects with the fewest chromosomal aberrations. This mixture exhibited the potential to be used as an anticancer drug owing to its abilities to exert antimitotic activity without causing extreme clastogenic effects. Paclitaxel, when used alone or in combination with coumarin at high concentrations (greater than 10 -12 ppm), demonstrated possible carcinogenic potential when used in cancer therapy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".