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Modified Kaplan-Meier Estimator Based on Competing Risks for Heavy Censoring Data

2013· article· en· W2141410053 on OpenAlexvenueno aff
Ali Zare

Bibliographic record

VenueInternational Journal of Statistics in Medical Research · 2013
Typearticle
Languageen
FieldMathematics
TopicStatistical Distribution Estimation and Applications
Canadian institutionsnot available
Fundersnot available
KeywordsCensoring (clinical trials)Kaplan–Meier estimatorEstimatorSurvival analysisStatisticsSurvival functionProportional hazards modelEconometricsMathematicsMedicine

Abstract

fetched live from OpenAlex

Most follow-up studies are conducted to determine the survival rates of subjects affected by a specific risk. These subjects are also exposed to other risks. Every subject in a medical follow-up is exposed not only to the risk of dying, but also to the risk of being censored. In case of heavy censoring, the Kaplan-Meier estimates are biased and overestimate the survival distribution. A new methodology based on competing risks is proposed to estimate the survival function by using net and crude probabilities. These estimates reduce the bias and overestimation of the survival distribution noted in Kaplan-Meier estimators. In this study, the method of modified Kaplan-Meier (MKM) is compared with the Kaplan-Meier (KM), Huang’s method and also the two other methods namely Weighted Kaplan-Meier (WKM) and Modified Weighted Kaplan-Meier (MWKM). Either of the weighted methods depends heavily on the event times and censoring distributions. Due to this fact, the weighted methods can have misleading results when the censoring patterns are different in the individual samples. The results showed that the MKM estimator considers not only the problem of heavy censoring but also the problem of weighted methods and competing risks in complicated data. In this study “Stanford Heart Transplant Data” was used to investigate the effectiveness of the proposed methods.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.070
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Methods · Consensus signal: none
Teacher disagreement score0.766
Threshold uncertainty score0.999

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.070
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.466
GPT teacher head0.586
Teacher spread0.120 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2013
Admission routes1
Has abstractyes

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