Clopidogrel use in children
Bibliographic record
Abstract
Background Children with congenital heart lesions have an increased incidence of thrombotic complications, particularly after interventional catheterization procedures. Clopidogrel is a specific platelet aggregation inhibitor. It selectively blocks the binding of membrane ADP to its platelet receptor. Dual therapy with aspirin and clopidogrel is the preferred antithrombotic regimen after coronary intervention with stent placement in adults. We describe the first experience with clopidogrel in children with complex heart disease after interventional cardiac catheterization and suggest a dose regimen for a pediatric population. Methods A retrospective study of all infants and children treated with clopidogrel bisulphate in the Hospital for Sick Children, Toronto between Jan. 2001 and April 2004. Clopidogrel dosages, duration of therapy, complications and adverse effects were explored. Results 15 infants and children with congenital and acquired heart disease were treated with clopidogrel (median age 3.5 years; range 6 weeks- 16 years). Dosages ranged from 1 to 6 mg/kg/day, for periods between 1 to 6 months. While no thrombotic events were reported, one child had a bleeding complication (gastrointestinal) while on triple antithrombotic therapy (warfarin, aspirin and clopidogrel). Other complications reported in adults were not noted in this pediatric series. Conclusions Clopidogrel was well tolerated. A dose of 1mg/kg/day for children, may be started with monitored bleeding time. Clinical Pharmacology & Therapeutics (2005) 77, P54–P54; doi: 10.1016/j.clpt.2004.12.098
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".