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Record W2141677872 · doi:10.1152/jn.01279.2007

Demystifying Spasticity: Reply to Dietz

2008· letter· en· W2141677872 on OpenAlexaff
David J. Bennett

Bibliographic record

VenueJournal of Neurophysiology · 2008
Typeletter
Languageen
FieldMedicine
TopicBotulinum Toxin and Related Neurological Disorders
Canadian institutionsUniversity of Alberta
FundersNational Institute of Neurological Disorders and Stroke
KeywordsSpasticityClonusMuscle toneHyperreflexiaHypertoniaPhysical medicine and rehabilitationConfusionSpasticNeuroscienceStretch reflexMuscle contractureMedicinePsychologyPsychoanalysisReflexCerebral palsyEpilepsy

Abstract

fetched live from OpenAlex

comparing his work on spasticity in humans to my studies of spasticity in the sacral spinal rat (Bennett et al. 2004).His comments highlight many of the confusions that have shrouded the study of spasticity and give me a chance to clear the air on this topic.The first confusion relates to the complexity of spasticity and the lack of consensus on which aspects of spasticity are most relevant.The spastic syndrome in humans (or what Dietz calls the "spastic movement disorder") is a complex collection of clinical conditions, including excess muscle tone (hypertonus), changes in muscle properties (like contractures), excess reflex activity (hyperreflexia), muscle oscillations (clonus), and massive uncontrolled motoneuron firing and contractions (spasms; Bennett et al. 2004;Dietz and Sinkjaer 2007;Kuhn and Macht 1948).In my laboratory, we mostly study spasms triggered by brief cutaneous stimulation and we have shown these to result from excess motoneuron excitability (Bennett et al. 2004; Li et al. 2004a).Dietz has spent a lot of time studying muscle properties (Dietz et al. 1986) and emphasizes their importance in his letter to the editor (Dietz 2007).From this perspective, he criticizes research that does not focus on muscle properties, suggesting that it is not relevant to the study of spasticity.This seems a bit odd because upward of 80% of spinal cord injured humans suffer from spasms caused by excess motoneuron activity (Maynard et al. 1990), and thus understanding spasms is important.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.097
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.006
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.277
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2008
Admission routes1
Has abstractyes

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