A Feedback Glucose Control Strategy for Type II Diabetes Mellitus
Why this work is in the frame
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Bibliographic record
Abstract
Type II diabetes mellitus is characterized by both insulin resistance and β-cell failure. Although patients with type II diabetes mellitus are not initially dependent on insulin, the introduction of insulin therapy becomes one of the most effective methods of attaining good glycemic control. In this work, a proportional-integral-derivative (PID) controller is implemented to maintain normoglycemia in a simulated Type II diabetic patient using a closed-loop insulin infusion pump. The simulation employs a compartment model, which represents the glucose regulatory system and includes submodels representing the absorption of subcutaneously administered short-acting insulin and gut absorption. The feedback control system returns blood glucose to normoglycemic ranges after a meal disturbance. The settling time is similar to that of a non-diabetic. These results demonstrate the potential use of control algorithms for regulation of blood glucose by insulin for Type II diabetic patients.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it