When is a desmoid not a desmoid? Endometrial cancer as an extracolonic manifestation of MYH Associated Polyposis (MAP)
Bibliographic record
Abstract
Background Desmoids are a recognized feature of the classical and attenuated forms of familial adenomatous polyposis (FAP), occurring in 15% of individuals with classic FAP. Case history A 68 year old Caucasian woman presented with a lump in her right groin and lower abdominal pain. No changes in bowel habit or other bowel symptoms were reported. Previous medical history included endometrial cancer diagnosed at age 57, treated by hysterectomy and bilateral salpingo-oophorectomy. The family history was negative for desmoids, colon polyps and cancer. By CT scan, a 4 x 3 cm soft tissue mass arising from the right rectus muscle and tethered to bowel loops was identified. It was felt to represent a desmoid. Before resecting this mass, due to bowel tethering, a colonoscopy was performed. The cecum was completely replaced by a carpeting villous adenoma. Two tubular adenomas and one tubulovillous adenoma, all with lowgrade dysplasia, were noted. During definitive surgery, the lesion arising from the sigmoid mesentery and suspected to be a desmoid, was shown to be a well-differentiated adenocarcinoma with endometrioid features. 28 tubulovillous adenomas and hyperplastic polyps, with no malignancy or dysplasia were identified in the subtotal colectomy. The clinical impression was that of attenuated polyposis and metastatic endometrial carcinoma. Results
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.019 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".