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Record W2143028090 · doi:10.1016/j.juro.2012.03.034

Intermittent Androgen Suppression—Ready for Prime Time?

2012· letter· en· W2143028090 on OpenAlexaffabout
Joseph Ischia, S. Larry Goldenberg

Bibliographic record

VenueThe Journal of Urology · 2012
Typeletter
Languageen
FieldMedicine
TopicProstate Cancer Diagnosis and Treatment
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsMedicineProstate cancerAndrogenAndrogen suppressionRandomized controlled trialInternal medicineOncologyCancerGynecologyUrologyHormone

Abstract

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No AccessJournal of UrologyEditorial1 Jun 2012Intermittent Androgen Suppression—Ready for Prime Time? Joseph Ischia and S. Larry Goldenberg Joseph IschiaJoseph Ischia More articles by this author and S. Larry GoldenbergS. Larry Goldenberg Financial interest and/or other relationship with Sanofi Canada and Abbott Canada. More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.03.034AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Intermittent Androgen Suppression—Ready for Prime Time?." The Journal of Urology, 187(6), pp. 1956–1957 References 1 : Intermittent androgen suppression for prostate cancer. Nat Rev Urol2010; 7: 552. Google Scholar 2 : Effects of androgen withdrawal on the stem cell composition of the Shionogi carcinoma. Cancer Res1990; 50: 2275. Google Scholar 3 : Randomised prospective study of intermittent versus continuous androgen suppression in advanced prostate cancer. J Clin Oncol2007; 25. abstract 5015. Google Scholar 4 : Phase III study of intermittent MAB vs continuous MAB. J Urol2011; 185: e288. abstract 716. Google Scholar 5 : A phase III randomized trial of intermittent versus continuous androgen suppression for PSA progression after radical therapy (NCIC CTG PR.7/SWOG JPR.7/CTSU JPR.7/ UK Intercontinental Trial CRUKE/01/013). J Clin Oncol2011; 29. abstract 4514. Google Scholar 6 : Absolute prostate-specific antigen value after androgen deprivation is a strong independent predictor of survival in new metastatic prostate cancer: data from Southwest Oncology Group Trial 9346 (INT-0162). J Clin Oncol2006; 24: 3984. Google Scholar 7 : Practice-based research–“Blue Highways” on the NIH roadmap. JAMA2007; 297: 403. Google Scholar 8 : Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report. Urology1995; 45: 839. Google Scholar Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada© 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 6June 2012Page: 1956-1957 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joseph Ischia More articles by this author S. Larry Goldenberg Financial interest and/or other relationship with Sanofi Canada and Abbott Canada. More articles by this author Expand All Advertisement PDF downloadLoading ...

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.207
Threshold uncertainty score0.692

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.009
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0040.005
Open science0.0010.002
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.2070.040

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.033
GPT teacher head0.302
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2012
Admission routes2
Has abstractyes

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