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Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

2010· article· en· 1,215 citations· W2143743183 on OpenAlex· 10.1038/mt.2010.85

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Classifier prediction

metacan-v1-d91a1de5be90

Predictions imitate two machine teachers. Scores are not calibrated prevalence probabilities.

Classifier candidate
Non-randomized trialBench or experimental
Classifier consensus
Bench or experimental
Teacher imitation scores

Codex

Bench or experimental1.000
Other design0.002
Theoretical or conceptual0.001
Observational0.001
Randomized trial0.000
Research integrity0.000
Simulation or modelling0.000
Case report0.000
Qualitative0.000
Metaresearch0.000
Scholarly communication0.000
Not applicable0.000
Meta-analysis0.000
Meta-epidemiology (narrow)0.000
Bibliometrics0.000
Open science0.000
Meta-epidemiology (broad)0.000
Science and technology studies0.000
Non-randomized trial0.000
Systematic review0.000

Gemma

Bench or experimental0.999
Not applicable0.002
Non-randomized trial0.001
Theoretical or conceptual0.001
Case report0.000
Observational0.000
Randomized trial0.000
Research integrity0.000
Qualitative0.000
Simulation or modelling0.000
Metaresearch0.000
Meta-analysis0.000
Science and technology studies0.000
Meta-epidemiology (narrow)0.000
Meta-epidemiology (broad)0.000
Open science0.000
Bibliometrics0.000
Scholarly communication0.000
Systematic review0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.013
GPT teacher head0.213
Teacher spread
0.200 how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering RNAs (siRNAs) to hepatocytes in vivo; however, the precise mechanism by which this efficient delivery occurs has yet to be elucidated. We found that apolipoprotein E (apoE), which plays a major role in the clearance and hepatocellular uptake of physiological lipoproteins, also acts as an endogenous targeting ligand for ionizable LNPs (iLNPs), but not cationic LNPs (cLNPs). The role of apoE was investigate…

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