Role of aldosterone in stress‐induced antinatriuresis in normotensive saline overload rats
Bibliographic record
Abstract
Abstract The aim of this study was to determine aldosterone participation in the stress‐induced antinatriuresis in normotensive saline overload rats, as a probable cause of stress‐induced hypertension. Spironolactone (Sp) 6 mg/kg/day, intraperitoneal injection, as a Mineralocorticoid receptor antagonist was used. The rats were divided into four groups: basal (B), basal drug (B‐Sp), stress [Immobilization stress (IMO)] and stress‐Sp (IMO‐Sp). Urinary Na + and K + were measured and the K + /Na + ratio was calculated. Aldosterone and corticosterone plasmatic levels were determined. Stressed rats showed higher aldosterone and corticosterone levels than the ones in the basal group. The antinatriuretic effect in response to acute IMO was not reverted with Sp. However, IMO‐Sp animals showed higher urinary sodium levels than IMO animals suggesting a partial inhibition of the stress response. The IMO‐Sp animals excreted 50 per cent of basal sodium while IMO animals excreted about 20 per cent of B sodium. This effect was also evidenced in the urinary K + /Na + ratio. In conclusion, aldosterone would be a factor influencing sodium reabsorption in stressed rats. Since sodium distal handling is small with respect the proximal ones, in which the sympathetic innervation is great, the inhibition of aldosterone action is not enough to revert antinatriuretic effect. Besides, the high levels of corticosterone might exert some effect on stress‐induced antinatriuresis. These results show the importance of aldosterone in the sodium reabsorption in IMO rats as a contributing factor to explain the origin of stress‐induced hypertension in rats. Copyright © 2008 John Wiley & Sons, Ltd.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".