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Record W2148510017 · doi:10.1093/jmp/jhu020

Why the Debate over Minimal Risk Needs to be Reconsidered

2014· article· en· W2148510017 on OpenAlexafffund
Ariella Binik, Charles Weijer

Bibliographic record

VenueThe Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · 2014
Typearticle
Languageen
FieldMedicine
TopicEthics in Clinical Research
Canadian institutionsWestern University
FundersCanadian Institutes of Health Research
KeywordsReferentInterpretation (philosophy)EpistemologyRelative riskPhilosophyMathematicsConfidence intervalStatistics

Abstract

fetched live from OpenAlex

Minimal risk is a central concept in the ethical analysis of research with children. It is defined as the risks ". . . ordinarily encountered in daily life . . . ." But the question arises: who is the referent for minimal risk? Commentators in the research ethics literature often answer this question by endorsing one of two possible interpretations: the uniform interpretation (which is also known as the absolute interpretation) or the relative interpretation of minimal risk. We argue that describing the debate over minimal risk as a disagreement between the uniform and the relative interpretation impedes progress on the identification of a justifiable referent for minimal risk. There are two main problems with this approach: (1) constructing the debate over minimal risk as a disagreement between a uniform and a relative interpretation misconstrues the main difference between competing interpretations and (2) neither the uniform nor the relative interpretation identifies one unique and consistent group of children as the referent for minimal risk. We conclude that progress on the debate over minimal risk requires that we abandon the uniform and relative interpretations and address the main moral problem at stake: whether healthy children or the subjects of the research should be the referent for minimal risk.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.212
metaresearch head score (Gemma)0.284
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.212
Threshold uncertainty score0.971

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.2120.284
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0040.003
Bibliometrics0.0030.003
Science and technology studies0.0110.119
Scholarly communication0.0200.062
Open science0.0120.013
Research integrity0.0440.066
Insufficient payload (model declined to judge)0.0050.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.361
GPT teacher head0.475
Teacher spread0.114 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2014
Admission routes2
Has abstractyes

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Same venueThe Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of MedicineSame topicEthics in Clinical ResearchFrench-language works237,207