Bibliographic record
Abstract
PURPOSE OF REVIEW: Allogeneic stem cell transplantation is a potentially curative treatment for some high-risk patients with acute myeloid leukemia, but wider use of this treatment is limited by donor availability. Although use of alternative donors in these patients is increasing, the role of alternative donors in these high-risk patients, especially in first remission, remains undefined. RECENT FINDINGS: Results of recent studies indicate that the outcomes with unrelated donors matched at allele levels (10/10) are similar to those in human leukocyte antigen identical sibling donor transplant recipients. Encouraging results have been reported in older patients with acute myeloid leukemia with the use of unrelated donors, extending the benefit of allografting to a wider patient population. Cord blood transplantation and haploidentical transplants are alternative options when a suitable unrelated donor is not available in a timely manner. Disease status at the time of transplantation appears to be a major determinant of outcome with any of these options because outcomes remain dismal for patients with active leukemia at transplantation. SUMMARY: Encouraging data from current studies indicate that the use of alternative donors in high-risk acute myeloid leukemia patients in first remission deserves prospective evaluation. This option should be included in future clinical trial designs.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".