Fast Phased Small RNA Cycle Counting Algorithms
Bibliographic record
Abstract
Counting phased small RNA cycles (PSRC) from mapped small RNA positions is a repeatedly invoked subproblem in the computation of identifying TRANS-ACTING siRNA (TAS) loci and loci of other small RNAs forming through mechanisms similar to that of trans-acting small interfering RNAs (ta-siRNAs). The efficiency of counting PSRC has a clear impact on the efficiency of the algorithms predicting these loci. There are two closely related variants on counting PSRC in real applications: WPSRC, which counts the number of distinct small RNAs falling onto the phased positions in a sliding window, and MPSRC, which counts the maximum consecutive PSRC from mapped small RNA positions. In this paper, we develop fast algorithms for both WPSRC and MPSRC. Our algorithms have O(max(S)) time complexity, while the existing algorithm and its variant have O(|S|·max(S)) and O(|S|·L) time complexity for MPSRC and WPSRC respectively, where S is a set of mapped small RNA positions and L the length of sliding window for WPSRC. Experimental results on two real-life datasets show that our algorithms are significantly faster than the existing algorithm and its variant. The proposed algorithms are applicable to TAS-like clusters with any PSRC length including 21-nt.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.008 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.004 | 0.002 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.007 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".