0450. Systemic dysregulation of the angiopoietin-1/2 system in adults undergoing cardiopulmonary bypass (CBP)
Bibliographic record
Abstract
Systemic capillary leak syndrome after cardiopulmonary bypass (CBP) is a well-known phenomenon, accompanied by interstitial fluid accumulation and inflammation, and can lead to end-organ failure or increased hospital length of stay (LOS). The pathophysiology responsible for capillary leak involves activation of inflammation, complement, and coagulation. The endothelium plays a central role in the activation of coagulation, and activated/dysregulated endothelium contributes to microvascular leak and enhanced adhesion of leukocytes. However, the characterization and measurement of endothelial dysregulation is not well established. Angiopoietin-1 (Ang-1) and -2 (Ang-2) are molecules implicated in angiogenesis and regulation of endothelial permeability. Their differential changes of expression could be a surrogate to quantify endothelial dysregulation after CBP.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".