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Record W2150237433 · doi:10.4212/cjhp.v61i4.64

Effect of an Educational Intervention on the Management of Ventilator-Associated Pneumonia

2008· article· en· W2150237433 on OpenAlexaffvenue
Zahra Kanji, Sandeep Singh Gill, Michael Boldt, Rajesh Mainra, Barb Van Wieren

Bibliographic record

VenueThe Canadian Journal of Hospital Pharmacy · 2008
Typearticle
Languageen
FieldMedicine
TopicNosocomial Infections in ICU
Canadian institutionsLions Gate Hospital
Fundersnot available
KeywordsMedicinePneumoniaDosingVentilator-associated pneumoniaEmpiric therapyIntervention (counseling)Intensive care medicineAntibiotic therapyIntensive care unitEmergency medicineAntibioticsInternal medicineNursingAlternative medicine

Abstract

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ABSTRACT Background: The publication of guidelines for the management of ventilator-associated pneumonia prompted an evaluation of management of this condition in the intensive care unit (ICU) of a community acute care hospital. Objectives: To evaluate the management of ventilatorassociated pneumonia before and after an educational intervention for physicians and to determine the pathogens responsible for this condition among patients in this ICU. Methods: The management of ventilator-associated pneumonia was reviewed, and compliance with published guidelines and with clinically appropriate therapy (in terms of subsequent culture results or local practice) was evaluated for the 7 months before and the 6 months after the 1-week educational intervention. Results: A total of 42 episodes of ventilator-associated pneumonia, which occurred in 37 patients, were evaluated. After the educational intervention, the following changes in end points were observed: appropriate selection of empiric antibiotic therapy according to guidelines increased from 35% of episodes before to 59% of episodes after the intervention (p = 0.11), whereas the selection of empiric therapy subsequently deemed to be clinically appropriate increased from 45% to 77% (p = 0.032); appropriate dosing according to guidelines increased from 20% to 33% (p = 0.33), whereas clinically appropriate dosing increased from 70% to 95% (p = 0.027); appropriate route of therapy according to the guidelines increased from 75% to 82% (p = 0.59) but there was no change in clinically appropriate route of therapy (100% in both phases); timeliness of therapy increased from 85% to 91% (p = 0.56), de-escalation (narrowing of empiric therapy on the basis of culture results) increased from 60% to 100% (p = 0.11), and appropriate duration of therapy decreased from 79% to 55% (p = 0.11). Conclusions: Clinically appropriate selection and dosing of antibiotics for ventilator-associated pneumonia improved after the educational intervention for physicians. The availability of local microbiological data was valuable in guiding empiric antibiotic selection. RESUME Contexte : L’accessibilite aux lignes directrices en matiere de traitement des cas de pneumonie sous ventilation assistee a incite une evaluation du traitement de ces cas dans une unite de soins intensifs d’un hopital communautaire de soins de courte duree. Objectifs : Evaluer le traitement des cas de pneumonie sous ventilation assistee avant et apres une intervention formative aupres des medecins et identifier les agents pathogenes responsables de ces cas a l’unite de soins intensifs. Methodologie : Nous avons examine le mode de traitement des cas de pneumonie sous ventilation assistee, la conformite aux lignes directrices publiees et la pertinence du traitement en fonction de la situation clinique (suivant les resultats de culture subsequents ou l’usage local) pendant sept mois avant l’intervention formative d’une semaine et pendant les six mois qui ont suivi. Resultats : Nous avons evalue un total de 42 episodes de pneumonie sous ventilation assistee chez 37 patients. Nous avons observe les changements suivants des criteres d’evaluation apres l’intervention : le choix de l’antibiotherapie empirique appropriee selon les lignes directrices a augmente, passant de 35 % des episodes avant l’intervention a 59 % des episodes apres l’intervention (p = 0,11), alors que le choix du traitement empirique juge ulterieurement pertinent en fonction de la situation clinique a monte de 45 % a 77 % (p = 0,032); la posologie appropriee selon les lignes directrices a augmente, passant de 20 % a 33 % (p = 0,33), tandis que la bonne posologie en fonction de la situation clinique a monte de 70 % a 95 % (p = 0,027); le choix de la voie de traitement appropriee selon les lignes directrices a augmente, passant de 75 % a 82 % (p = 0,59), mais il n’y a eu aucun changement dans le pourcentage du choix de la bonne voie de traitement en fonction de la situation clinique (100 % dans les deux phases); l’opportunite du traitement a augmente, passant de 85 % a 91 % (p = 0,56), de meme que la desescalade (la restriction du traitement empirique suivant les resultats de culture), passant de 60 % a 100 % (p = 0,11); la duree appropriee du traitement a chute de 79 % a 55 % (p = 0,11). Conclusions : Il y a eu une amelioration dans le choix approprie du traitement en fonction de la situation clinique et dans la posologie des antibiotiques pour les cas de pneumonie sous ventilation assistee apres l’intervention formative aupres des medecins. L’acces aux donnees microbiologiques locales a ete d’une grande utilite pour guider le choix de l’antibiotherapie empirique.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.009
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.017
GPT teacher head0.320
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2008
Admission routes2
Has abstractyes

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