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Record W2151645052 · doi:10.1038/ng.2754

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

2013· article· en· W2151645052 on OpenAlexafffund
Sohela Shah, Kasmintan A. Schrader, Esmé Waanders, Andrew E. Timms, Joseph Vijai, Cornelius Miething, Jeremy Wechsler, Jun J. Yang, James E. Hayes, Robert J. Klein, Jinghui Zhang, Lei Wei, Gang Wu, Michael Rusch, Panduka Nagahawatte, Jing Ma, Shann-Ching Chen, Guangchun Song, Jinjun Cheng, Paul A. Meyers, Deepa Bhojwani, Suresh C. Jhanwar, P. Maslak, Martin Fleisher, Jason Littman, Lily Offit, Rohini Rau‐Murthy, Megan Harlan Fleischut, Marina Corines, Rajmohan Murali, Xiaoni Gao, Christopher Manschreck, Thomas Kitzing, Vundavalli V. Murty, Susana C. Raimondi, Roland P. Kuiper, Annet Simons, Joshua D. Schiffman, Kenan Onel, Sharon E. Plon, David A. Wheeler, Deborah Ritter, David S. Ziegler, Kathy Tucker, Rosemary Sutton, Georgia Chenevix‐Trench, Jun Li, David G. Huntsman, Samantha Hansford, Janine Senz, Tom Walsh, Ming Lee, Christopher N Hahn, Kathryn G. Roberts, Mary‐Claire King, Sarah M. Lo, Ross L. Levine, Agnès Viale, Nicholas D. Socci, Katherine L. Nathanson, Hamish S. Scott, Mark J. Daly, Steven M. Lipkin, Scott W. Lowe, James R. Downing, David Altshuler, John T. Sandlund, Marshall S. Horwitz, Charles G. Mullighan, Kenneth Offit

Bibliographic record

VenueNature Genetics · 2013
Typearticle
Languageen
FieldMedicine
TopicAcute Lymphoblastic Leukemia research
Canadian institutionsUniversity of British Columbia
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesNational Health and Medical Research CouncilKWF KankerbestrijdingNational Cancer InstituteNational Institutes of HealthCanadian Institutes of Health ResearchGeoffrey Beene Cancer Research CenterAmerican Lebanese Syrian Associated CharitiesNational Institute of General Medical SciencesMedical Research CouncilDeutsche ForschungsgemeinschaftSt. Jude Children's Research Hospital
KeywordsBiologyPAX5Loss of heterozygosityGermlineGermline mutationGeneticsMutationAlleleMolecular biologyB cellSomatic cellCancer researchGeneTranscription factorAntibody

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.293
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations329
Published2013
Admission routes2
Has abstractno

Explore more

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