Isolation of Pulmonary Veins Using a Transvenous Curvilinear Cryoablation Catheter: Feasibility, Initial Experience, and Analysis of Recurrences
Bibliographic record
Abstract
INTRODUCTION: Pulmonary vein isolation (PVI) using focal cryothermal catheters is safe and moderately effective, but associated with long procedure times. We hypothesized that a linear freezing segment could shorten fluoroscopic and procedure times. We report our initial experience with a novel circular cryothermal catheter. METHODS AND RESULTS: Complete PV isolation (PVI) was achieved in 41 of 45 PVs by cryoablation (91%) in 18 patients who underwent Lasso-guided cryothermal using a novel 7 F circular catheter (2.5 +/- 0.7 veins per patient). A mean of 27.2 +/- 11 applications per patient (9.2 +/- 4.7 per vein) with a mean temperature -79.8 +/- 4 degrees C were delivered. Recorded temperatures did not predict complete or incomplete isolation. Focal cryothermal ablation using a 7 F 4-mm tip was required in the remainder for isolation. During 14.8 +/- 6.2 month follow-up, 4 (22%) had no recurrence of AF, and 7/18 (39%) had >90% reduction in symptoms without antiarrhythmic agents (AAA). Computed tomography scans at 3 months showed no stenosis (14.1 +/- 2.5 mm, 13.9 +/- 2.4 mm; P = 0.2). Eight patients underwent repeat ablation. Mapping demonstrated 13 of 14 (93%) previously isolated veins had recovery of over 64 +/- 24% of the ostium. All were successfully isolated with RF and 7 of 8 were arrhythmia free 6.0 +/- 2.9 months after ablation. Overall, 14 of 18 (78%) patients had their arrhythmia clinically controlled without drugs after one or two procedures. CONCLUSIONS: Our initial experience demonstrates safety and feasibility of circular cryothermal ablation with less fluoroscopic and procedure times as compared to focal cryothermy. As with RF, complete and permanent isolation of the PVs is not easily achieved. Reducing heat load due to PV flow may improve results.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".