Efficacy of ruxolitinib on hepatomegaly in patients with myelofibrosis
Bibliographic record
Abstract
The Janus kinase 1/2 inhibitor ruxolitinib has been shown in a pivotal placebo-controlled phase III study (Controlled Myelofibrosis Study with Oral JAK Inhibitor Treatment I (COMFORT-I)) to significantly reduce splenomegaly and symptoms in patients with intermediate-2 or high-risk myelofibrosis (MF). Although splenomegaly is the most common manifestation of MF-associated extramedullary hematopoiesis, up to 65% of patients may also have hepatomegaly, 1 , 2 which is often highly symptomatic and can lead to serious complications. 3 Here, we present the results from a COMFORT-I post hoc analysis that assessed changes in liver volume and their relationship with concomitant changes in splenomegaly and measures of metabolic status.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".