Effects of various toxicants on uptake of amino acids and their incorporation into proteins by Tetrahymena pyriformis
Bibliographic record
Abstract
Dupartement de Chimie et Biochimie, Universitu de Moncton, Canada Summary We have investigated the effect of various inorganic and organic toxicants on uptake of amino acids and their incorporation into proteins by Tetrahymena pyriformis. We have studied some heavy metalsCd, Cu, Zn and Cr (dichromate) and organic compounds (2,4�dinitrophenol, sodium pentachlorophenate, 4�chlorophenol and the pesticide Dicamba™). All these toxicants inhibited both activities. Furthermore, the inhibition patterns of amino acid uptake and protein synthesis were similar. This resemblance was observed with variously labeled amino acids: (35S)�methionine, a mixture of ( 35S)� methionine and (35S)�cysteine or a mixture of ( 14C)�amino acids. The ratios of inhibition of amino acid uptake/incorporation were quite close to one in most cases. Most probably, the toxicants tested inhibited protein synthesis and amino acid uptake indirectly, by affecting some other cell process influencing both uptake and incorporation. These results urge to exercise caution when interpreting data on the effect of toxicants on protein synthesis.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".