Cabazitaxel for Metastatic Castrate-Resistant Prostate Cancer: A Case Presentation
Bibliographic record
Abstract
Introduction: Although cabazitaxel was proven efficacious by a large Phase III trial and was approved for second-line treatment of metastatic castrate-resistant prostate cancer, case reports describing its efficacy and safety are lacking in the literature. More data is needed describing castrate-resistant prostate cancer cases that progress with 1st line therapy. Case Presentation: A 78-year old Hispanic male presented to the clinic in July 2011 with a 3-month history of worsening left knee pain, generalized fatigue, and a 5.4 kilogram weight loss. His past medical history was significant for metastatic prostate cancer and his laboratory results were notable for an alkaline phosphatase of 221U/L, a prostate specific antigen of 837.7ng/ml, and a creatinine of 1.94. Discussion: Metastatic prostate cancer results from the combination of lymphatic, blood, or contiguous local spread. Cabazitaxel is a novel semi-synthetic tubulin binding taxane that uses a precursor molecule extracted from yew tree needles. In the phase III TROPIC study, CRPC patients previously taking docetaxel had a significant increase in overall survival with cabazitaxel compared with mitoxantrone (15.1 vs. 12.7 months, p<0.001). Conclusion: Cabazitaxel appears to be safe chemotherapeutic agent and has moved to the forefront in our armamentarium for the treatment in castrate-resistant prostate cancer.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".