Paroxetine improves social anxiety disorder in children and adolescents
Bibliographic record
Abstract
Wagner KD, Berard R, Stein MB, et al . A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Arch Gen Psychiatry 2004;61:1153–62.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Is paroxetine effective and well tolerated in children and adolescents with social anxiety disorder? ### ![Graphic][5] Design: Randomised controlled trial. ### ![Graphic][6] Allocation: Concealed. ### ![Graphic][7] Blinding: Double blinded. ### ![Graphic][8] Follow up period: 16 weeks. ### ![Graphic][9] Setting: 38 centres in the USA, South Africa, Canada, and Belgium; enrolment November 1999 to October 2001. ### ![Graphic][10] Patients: 322 children and adolescents (8–17 years) with social anxiety disorder (DSM-IV). Exclusions: other axis I disorder; experiencing a major depressive episode or suicidal tendencies; history of bipolar disorder, psychosis, developmental disorder, or serious medical condition; receiving psychoactive medication or therapy; recent electroconvulsive therapy; substance abuse; hypersensitivity to serotonin selective reuptake inhibitors (SSRIs); pregnant or lactating; or abnormal laboratory or ECG results. ### ![Graphic][11] Intervention: Paroxetine (10 mg/day for the first week, increased by 10 mg/week up to a maximum dose of 50 … [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BGeneral%2BPsychiatry%26rft.stitle%253DArch%2BGen%2BPsychiatry%26rft.aulast%253DWagner%26rft.auinit1%253DK.%2BD.%26rft.volume%253D61%26rft.issue%253D11%26rft.spage%253D1153%26rft.epage%253D1162%26rft.atitle%253DA%2BMulticenter%252C%2BRandomized%252C%2BDouble-blind%252C%2BPlacebo-Controlled%2BTrial%2Bof%2BParoxetine%2Bin%2BChildren%2Band%2BAdolescents%2BWith%2BSocial%2BAnxiety%2BDisorder%26rft_id%253Dinfo%253Adoi%252F10.1001%252Farchpsyc.61.11.1153%26rft_id%253Dinfo%253Apmid%252F15520363%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/archpsyc.61.11.1153&link_type=DOI [3]: /lookup/external-ref?access_num=15520363&link_type=MED&atom=%2Febmental%2F8%2F2%2F43.atom [4]: /lookup/external-ref?access_num=000224898700010&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".