Expression of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing rabbits compared with diet-restricted rabbits
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Study of apoptosis regulatory proteins in skeletal muscle of tumor-bearing rabbits; the object is cachexia biology.
The study examines apoptosis in tumor-bearing rabbits, not research practice.
Biomedical study of apoptosis proteins in tumor-bearing rabbits; laboratory biology.
Abstract
The mechanism of body weight loss in the tumor-bearing state is still unclear. In this study, we investigated expressions of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing and diet-restricted rabbits, and tried to evaluate the differences between the two groups. The apoptotic index (AI) in the tumor-bearing group was 28.1+/-2.84 on day 10. By day 20, many more apoptotic cells were found (AI: 40.5+/-3.20), but then after day 20 their numbers gradually decreased (AI: 9.67+/-2.22 on day 30 and 0.93+/-0.96 on day 40). By contrast, no apoptotic cells were detected in the diet-restricted group at any of the times examined. Bcl-2 immunoreactivity was either not detected at all or only weakly observed in both groups. By contrast, Bax expression increased gradually after implantation in the tumor-bearing group. Bax expression in skeletal muscle cell was graded (moderate) 10 days after tumor implantation, and (high) by day 20, in 2 of the 5 tumor-bearing rabbits. After day 20, however, Bax immunoreactivity decreased continuously in the tumor-bearing group. By contrast, hardly any Bax-immuno-positive cells were detected in the diet-restricted group. These results suggest that loss of body weight in the tumor-bearing group is different from that in the diet-restricted group, and is related to apoptosis of skeletal muscles.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- International Journal of Molecular Medicine
- Topic
- Rabbits: Nutrition, Reproduction, Health
- Field
- Agricultural and Biological Sciences
- Canadian institutions
- —
- Funders
- Terry Fox FoundationMassachusetts General Hospital
- Keywords
- ApoptosisOncogeneSkeletal muscleMolecular medicineBiologyBAX ProteinCell cycleInternal medicineEndocrinologyGroup AAndrologyPathologyGeneProtein expressionMedicineBiochemistry
- Has abstract in OpenAlex
- yes