Bibliographic record
Abstract
Resume Objectif : Determiner les meilleures modalites de traitement du lymphome de Hodgkin. Sources des donnees : Une revue de la litterature scientifique a ete effectuee a l’aide de la base de donnees Pubmed (periode 1990-2010 et mots cles : Hodgkin, adulte). Des references secondaires et tertiaires ont egalement ete consultees. Analyse des donnees : Beaucoup d’etudes sont effectuees aupres de patients atteints du lymphome de Hodgkin. L’ABVD (doxorubicine, bleomycine, vinblastine et dacarbazine) est presentement le traitement standard autant pour les stades localises qu’avances. Il s’est avere au moins aussi efficace que la plupart des autres protocoles etudies tout en etant moins toxique autant a court qu’a long terme. Le seul protocole qui pourrait s’averer superieur a l’ABVD est le BEACOPP (bleomycine, etoposide, doxorubicine, cyclophosphamide, vincristine, procarbazine et prednisone). Cependant, sa toxicite superieure limite son utilisation pour le moment. La radiotherapie est aussi une pierre angulaire du traitement, principalement pour les maladies localisees. Son utilisation lors de maladies avancees est plus controversee. Conclusion : Meme si le lymphome de Hodgkin a un taux de guerison eleve par rapport a d’autres cancers, la gestion des toxicites a long terme, le traitement des rechutes ou le traitement des cas resistants demeurent des defis pour les annees a venir. Abstract Objective: To determine the optimal treatment modalities of Hodgkin’s disease. Data sources: A review of the scientific literature from 1996 to 2006 was done on Pubmed using the following key words : Hodgkin’s, adult. Secondary and tertiary references were also consulted. Data analysis: Many studies have been done in patients with Hodgkin’s disease. ABVD is currently the standard of care for both localized and advanced stages of the disease. It was found to be at least as effective as most protocols while having less long term and short term toxicity. The only protocol that may be superior to ABVD is the BEACOPP protocol (bleomycin, etoposide, doxorubicin, cyclophoshamide, vincristine, procarbazine and prednisone). However, its significant toxicity profile limits its use for the moment. Radiotherapy is also a cornerstone of treatment, mainly for localized disease. The use of radiotherapy in more advanced stages of the disease is controversial. Conclusion: Even though Hodgkin’s disease has a high cure rate as compared to other cancers, the management of long term toxicity, relapses and refractory cases remain challenging. Key words: Hodgkin’s lymphoma, chemotherapy, ABVD, BEACOPP, Stanford V, adverse reactions.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.022 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".