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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne Jackson, Eleanor Wheeler, Nicole L. Glazer, Nabila Bouatia‐Naji, Anna L. Gloyn, Cecilia M. Lindgren, Reedik Mägi, Andrew P. Morris, Joshua C. Randall, Toby Johnson, Paul Elliott, Denis Rybin, Guðmar Þorleifsson, Valgerður Steinthórsdóttir, Peter Henneman, Harald Grallert, Abbas Dehghan, Jouke‐Jan Hottenga, C. Franklin, Pau Navarro, Kijoung Song, Anuj Goel, John R. B. Perry, Josephine M. Egan, Taina K. Lajunen, Niels Grarup, Thomas Sparsø, Alex S. F. Doney, Benjamin F. Voight, Heather M. Stringham, Man Li, Stavroula Kanoni, Peter Shrader, Christine Cavalcanti-Proença, Meena Kumari, Lu Qi, Nicholas J. Timpson, Christian Gieger, Katja K.H. Aben, Ghislain Rocheleau, Erik Ingelsson, Ping An, Jeffrey R. O’Connell, Jian’an Luan, Amanda Elliott, Steven A. McCarroll, Felicity Payne, Rosa Maria Roccasecca, François Pattou, Praveen Sethupathy, Kristin Ardlie, Yavuz Ariyürek, Beverley Balkau, Philip J. Barter, John Beilby, Yoav Ben‐Shlomo, Rafn Benediktsson, Amanda J. Bennett, Richard N. Bergman, Murielle Bochud, Eric Boerwinkle, Amélie Bonnefond, Lori L. Bonnycastle, Knut Borch‐Johnsen, Yvonne Böttcher, Eric J. Brunner, Suzannah J. Bumpstead, G. Charpentier, Yii‐Der Ida Chen, Peter S. Chines, Robert Clarke, Lachlan Coin, Matthew N. Cooper, Marilyn C. Cornelis, Gabe Crawford, Laura Crisponi, Ian N.M. Day, Eco J. C. de Geus, Jérôme Delplanque, Christian Dina, Michael R. Erdos, Annette C. Fedson, Antje Fischer‐Rosinsky, Nita G. Forouhi, Caroline S. Fox, Rune R. Frants, Maria Grazia Franzosi, Pilar Galán, Mark O. Goodarzi, J. Graessler, Christopher J. Groves, Scott M. Grundy, Rhian Gwilliam, Ulf Gyllensten, Samy Hadjadj, Göran Hallmans, Naomi Hammond, Xijing Han, Anna‐Liisa Hartikainen, Neelam Hassanali, Caroline Hayward, Simon Heath, Serge Herçberg, Christian Herder, Andrew A. Hicks, David R. Hillman, Aroon D. Hingorani, Albert Hofman, Jennie Hui, Bo Isomaa, Paul R V Johnson, Torben Jørgensen, Antti Jula, Marika Kaakinen, Jaakko Kaprio, Y. Antero Kesäniemi, Mika Kivimäki, Beatrice Knight, Seppo Koskinen, Péter Kovács, Kirsten Ohm Kyvik, G.M. Lathrop, Debbie A. Lawlor, Olivier Le Bacquer, Cécile Lecœur, Yun Li, Valeriya Lyssenko, Robert W. Mahley, Massimo Mangino, Nicholas G. Martin, Jarred B. McAteer, Laura McCulloch, Ruth McPherson, Christa Meisinger, David Melzer, Stephen Eyre, Braxton D. Mitchell, Mario A. Morken, Sutapa Mukherjee, Silvia Naitza, Narisu Narisu, Matthew Neville, Ben A. Oostra, Marco Orrù, Ruth Pakyz, Giuseppe Paolisso, Cristian Pattaro, Daniel S. Pearson, John F. Peden, Nancy L. Pedersen, Markus Perola, Andreas Pfeiffer, Irene Pichler, Ozren Polašek, Daniëlle Posthuma, Simon Potter, Anneli Pouta, Michael A. Province, Bruce M. Psaty, Wolfgang Rathmann, Nigel W. Rayner, Kenneth Rice, Samuli Ripatti, Fernando Rivadeneira, Michael Roden, Olov Rolandsson, Annelli Sandbæk, Manjinder S. Sandhu, Serena Sanna, Avan Aihie Sayer, Paul Scheet, Laura J. Scott, Udo Seedorf, Stephen J. Sharp, Beverley M. Shields, Gunnar Sigurðsson, Eric J.G. Sijbrands, Angela Silveira, Laila Simpson, Andrew B. Singleton, Nicholas L. Smith, Ulla Sovio, Amy J. Swift, Holly Syddall, Ann‐Christine Syvänen, Toshiko Tanaka, Barbara Thorand, Jean Tichet, Anke Tönjes, André G. Uitterlinden, Ko Willems van Dijk, Mandy van Hoek, Dhiraj Varma, Sophie Visvikis‐Siest, Véronique Vitart, Nicole Vogelzangs, Gérard Waeber, Peter J. Wagner, Andrew J. Walley, G. Bragi Walters, Kim L Ward, Hugh Watkins, Michael N. Weedon, Sarah H. Wild, Gonneke Willemsen, J. C. M. Witteman, J. W. G. Yarnell, Eleftheria Zeggini, Diana Zélénika, Björn Zethelius, Guangju Zhai, Wei Zhao, M. Carola Zillikens, Ingrid B. Borecki, Ruth J. F. Loos, Pierre Meneton, Patrik K. E. Magnusson, David M. Nathan, Gordon H. Williams, Andrew T. Hattersley, Kaisa Silander, Veikko Salomaa, George Davey Smith, Stefan R. Bornstein, Peter E. H. Schwarz, Joachim Spranger, Fredrik Karpe, Alan R. Shuldiner, Cyrus Cooper, George Dedoussis, Manuel Serrano‐Ríos, Andrew D. Morris, Lars Lind, Lyle J. Palmer, Frank B. Hu, Paul W. Franks, Shah Ebrahim, Michael Marmot, W.H. Linda Kao, James S. Pankow, Michael Sampson, Johanna Kuusisto, Markku Laakso, Torben Hansen, Oluf Pedersen, Peter P. Pramstaller, H.‐Erich Wichmann, Thomas Illig, Igor Rudan, Alan F. Wright, Michael Stümvoll, Harry Campbell, James F. Wilson
Bibliographic record
VenueNature Genetics · 2010
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Associations and Epidemiology
Canadian institutionsUniversity of OttawaMcGill University and Génome Québec Innovation CentreMcGill University
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesEconomic and Social Research CouncilNational Institute for Health and Care ResearchBritish Heart FoundationWellcome Trust
KeywordsBiologyInsulin resistanceType 2 diabetesGlucose homeostasisInternal medicineGenome-wide association studyGlycemicEndocrinologyDiabetes mellitusGenetic associationInsulinCandidate geneImpaired fasting glucoseGeneticsImpaired glucose toleranceGeneGenotypeSingle-nucleotide polymorphismMedicine
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.004
Threshold uncertainty score0.012
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.006
GPT teacher head0.263
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations2,228
Published2010
Admission routes1
Has abstractno