Variation in adhesion and germ tube formation of oral<i>Candida</i>using Egyptian propolis
Bibliographic record
Abstract
Adhesion of Candida cells to surfaces is considered the first step in colonization. Some natural products, such as propolis, could be used to block cell adhesion and therefore preventing colonization. In this study, Egyptian propolis ethanol extract concentrations in the range of 25 to 125 ng/μL were used to inhibit the adhesion of oral Candida. The exopolysaccharides showed a 2.5-fold decrease, while the surface-bound exopolysaccharides showed only about 1.15-fold decrease. On the other hand, surface-bound proteins decreased by 7.5-fold upon the addition of 75 ng/μL propolis. The inhibition of adhesion was detected by scanning electron microscopy. The non-slip incubation assay showed a significant decrease in germ tube formation (GTF) compared with an increase upon the addition of fetal bovine serum and corn meal, both of which had a positive effect on GTF compared with a negative GTF effect when using propolis, suggesting that propolis could be considered a quorum-sensing molecule. The use of propolis would help in maintaining the cleanliness of dental fixtures and (or) treating recurrent candidiasis as a complementary and alternative treatment, especially in elders and immunocompromised patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".