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HOMOCYSTEINE AND MALONDIALDEHYDE AS PREDICTORS OF RESTENOSIS FOLLOWING PERCUTANEOUS CORONARY INTERVENTION

2006· article· en· W2159856947 on OpenAlex
C. Robert E. Wells, Mabood Qureshi, Kailash Prasad

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueASAIO Journal · 2006
Typearticle
Languageen
FieldMedicine
TopicCardiac Imaging and Diagnostics
Canadian institutionsRoyal University HospitalUniversity of Saskatchewan
Fundersnot available
KeywordsRestenosisConventional PCIMedicineHomocysteinePercutaneous coronary interventionInternal medicineCardiologyPlasma homocysteineMyocardial infarctionStent

Abstract

fetched live from OpenAlex

Restenosis is one of the major adverse outcomes of Percutaneous Coronary Intervention (PCI). The purpose of this study is to determine whether or not serum MDA and plasma homocysteine levels are elevated in patients who develop restenosis post PCI. The study included fifty-one patients undergoing elective PCI. Blood samples were collected pre-procedural, 0 time, 8 hours, 24 hours, and 6 months post-procedure. The results of the study showed that the pre-procedural levels of plasma homocysteine were significantly different from those of the post-PCI values in the restenosis group. In the restenosis group there was a significant increase (24%) after six months in the values of homocysteine from the pre-procedural levels. The values of serum MDA increased significantly at six months post-PCI in patients with restenosis. The levels of serum MDA in patients with restenosis at six months increased by one hundred and thirty-eight percent and were significantly different in the restenosis group. The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. However, the post-PCI six month levels of both homocysteine and MDA are predictors of restenosis. Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months, than the rise in homocysteine levels at the same time interval.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.055
Threshold uncertainty score0.382

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.246
Teacher spread0.241 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it