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Record W2160153983 · doi:10.1542/neo.7-4-e189

An Obstetric Point of View on Fetal Adaptation and Reprogramming

2006· article· en· W2160153983 on OpenAlex
Robert Gagnon

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNeoReviews · 2006
Typearticle
Languageen
FieldMedicine
TopicBirth, Development, and Health
Canadian institutionsWestern University
Fundersnot available
KeywordsMedicineReprogrammingAdaptation (eye)FetusPoint (geometry)ObstetricsPregnancyNeuroscienceGenetics

Abstract

fetched live from OpenAlex

After completing this article, readers should be able to: 1. Define the difference between fetal adaptation and fetal programming. 2. Describe the mechanisms involved in maintaining fetal oxygenation. 3. Describe how maternal glycemic control affects fetal growth and development. 4. List the known stimuli involved in fetal programming in humans. For pregnant women who want to have healthy babies and their obstetricians, the period extending from several weeks prior to conception until birth is of obvious interest. Problems affecting pregnancy may have consequences on the developing fetus resulting from adaptation or reprogramming. An adaptation is the action or process of adapting or being adapted. Adaptation implies a change by which an organism becomes better suited to its environment. Programming describes the mechanisms by which a stimulus or insult at a critical period of development has lasting or lifelong effects. Pregnancy affects all the determinants of oxygen delivery to the uteroplacental circulation. Maternal ventilation increases, which normally does not change arterial O2 saturation, although mild respiratory alkalosis ensues. Maternal hemoglobin concentrations decline due to greater expansion of plasma than red cell mass and reduced arterial O2 content. A rise in uteroplacental blood flow is due to higher cardiac output and redistribution of blood flow to favor uteroplacental circulation. Maternal cardiac output increases as a result of a decrease in systemic vascular resistance that begins in the luteal phase immediately following conception and an increase in blood volume. The fetus lives and grows in a relatively “hypoxic” environment compared with the adult. The fetal arterial Po2 is approximately 20 mm Hg compared with approximately 80 mm Hg in adults. The low fetal arterial Po2 can be attributed largely to the venous equilibration of placental gas exchange in which both maternal uterine venous and fetal umbilical venous vasculature streams run in …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.979
Threshold uncertainty score0.281

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.057
GPT teacher head0.327
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it