Dedication: Jim Orzechowski (1944–2003) and Michael Kiley (1942–2004)
Bibliographic record
Abstract
This supplement to the Journal of Infectious Diseases is dedicated to the memories of Jim Orzechowski (1944–2003) and Michael Kiley (1942–2004), individuals who were instrumental in bringing biosafety level 4 (BSL4) biocontainment into the 21st century. Jim Orzechowski, a Canadian from the prairies of Manitoba, received a degree in architecture fromNorth Dakota State University in 1970, joined the architectural firm of Smith Carter, and, within 4 years, was a partner in the company. Beginning in 1978, Smith Carter began designing medical structures, and, in 1987, Jim led a consortium that won the bid to build new laboratories for Canada's health and agriculture ministries. Patient and always careful, the team took more than 5 years to design what has become the prototype for modern BSL4 laboratories. The Canadian Science Centre for Human and Animal Health (CSCHAH) was dedicated in 1999 and has already contributed major new knowledge to high-containment biomedical science. Jim's company now designs BSL4 laboratories in the United States and beyond. Michael Kiley was born in Saratoga Springs, New York. His dad was a physician from a family with longstanding ties to Notre Dame University. After graduating from that institution, Mike earned a Ph.D. at the University of Virginia and eventually joined the Special Pathogens Branch at the Centers for Disease Control and Prevention (CDC) as a young molecular virologist. He performed some of the first molecular work ever in the positive-pressure “space suit” mode. The subjects were Ebola and Marburg viruses. Mike became client representative during construction of Building 15 at the CDC in the mid-1980s and then moved to the National Institutes of Health (NIH) as a biosafety expert. During that time, he joined 2 other colleagues to provide scientific and containment review as design proceeded for the CSCHAH, and he finally left the NIH to work full time in Winnipeg as plans were finalized and construction began. At the time of his death, Mike was chief biosafety officer for the US Department of Agriculture. These men have left a visible, poignant legacy that shall endure for many decades. We shall not see their like again. Supplement sponsorship. This article was published as part of a supplement entitled “Filoviruses: Recent Advances and Future Challenges,” sponsored by the Public Health Agency of Canada, the National Institutes of Health, the Canadian Institutes of Health Research, Cangene, CUH2A, Smith Carter, Hemisphere Engineering, Crucell, and the International Centre for Infectious Diseases. Jim Orzechowski Michael Kiley
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.022 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.002 | 0.001 |
| Scholarly communication | 0.004 | 0.002 |
| Open science | 0.002 | 0.004 |
| Research integrity | 0.002 | 0.005 |
| Insufficient payload (model declined to judge) | 0.167 | 0.102 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".