The Role of Penicillin G Potassium in Managing Clostridium perfringens in Broiler Chickens
Bibliographic record
Abstract
The efficacy of penicillin G potassium (Pot-Pen) administered via drinking water to manage necrotic enteritis (NE) was investigated in a Clostridium perfringens (CP) challenge study using 1600 broiler chickens assigned to one of four treatment groups: nonchallenged, nonmedicated; challenged, nonmedicated; challenged, Pot-Pen 0.2 g/L; challenged, Pot-Pen 0.4 g/L. Overall mortality due to NE was significantly reduced among Pot-Pen–treated pens; mortality due to other causes did not differ among the treatment groups. Among all birds, growth performance parameters were significantly improved among Pot-Pen–treated pens. When considering birds randomly sacrificed 4 days post-Pot-Pen initiation, mean NE lesion scores were greatest among the challenged, nonmedicated pens; only one of 80 randomly sacrificed birds treated with Pot-Pen had NE lesions. Among the nonmedicated control pens, body weight (BW) was significantly greater among birds that did not have NE-associated lesions. When sacrificed birds were stratified by NE lesion score, there were no significant differences in BW among the treatment groups. Results of this study suggest that CP-associated subclinical disease can significantly reduce broiler performance. Furthermore, the positive effects of treatment with Pot-Pen appeared to be associated with the prevention and/or treatment of NE-specific lesions.El papel de la penicilina G potásica en el manejo del Clostridium perfringens en pollos de engorde.Mediante un estudio de desafío de Clostridium perfringens, se investigó la eficacia de la penicilina G potásica administrada en el agua de bebida para el manejo de la enteritis necrótica. Se utilizaron 1600 pollos de engorde asignados a cuatro tratamientos: 1) no desafiados / no medicados; 2) desafiados / no medicados; 3) desafiados / medicados con penicilina G 0.2 g/L; 4) desafiados / medicados con penicilina G 0.4 g/L. En general, la mortalidad debido a enteritis necrótica se redujo en los corrales tratados con penicilina G, mientras la mortalidad por otras causas no difirió entre tratamientos. Los parámetros productivos se incrementaron significativamente en los grupos tratados. Analizando aves sacrificadas aleatoriamente 4 días posteriores a la administración de la penicilina G, el promedio del registro de lesiones entre las aves desafiadas / no medicadas fue el más alto; solo una de 80 aves tratadas con penicilina G mostró lesiones de enteritis necrótica. Entre los corrales no medicados, el peso corporal fue mayor en las aves que no mostraron lesiones asociadas con enteritis necrótica. Una vez sacrificadas, las aves se clasificaron en base al registro de lesiones. No se observaron diferencias significativas en el peso corporal entre los tratamientos. Los resultados de este estudio sugieren que la enfermedad subclínica asociada con Clostridium perfringens puede reducir significativamente el rendimiento productivo de los pollos de engorde. Además, los efectos positivos del tratamiento con penicilina G están aparentemente asociados con la prevención y/o tratamiento de lesiones específicas de enteritis necrótica.Abbreviations: BW = body weight; CP = Clostridium perfringens; FCR = feed conversion ratio; NE = necrotic enteritis; Pot-Pen = penicillin G potassium
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".