O4‐08‐02: THE ASSOCIATION BETWEEN LIFETIME OCCUPATIONAL EXPOSURE TO PESTICIDES AND COGNITIVE DECLINE IN THE ELDERLY
Bibliographic record
Abstract
Pesticide exposure has been associated with AD in some studies; however few, if any, studies have evaluated the effect of pesticides on cognitive decline. We previously reported an increased risk of AD among pesticide users in the Cache County Memory Study (CCMS). Using additional years of follow-up from this longitudinal study of memory and aging, we sought to determine whether pesticide exposure influences cognitive function over time and whether any such effects differ by APOE ε4 status. A total of 3,082 nondemented participants aged 65+ completed baseline evaluations, which included a modified version of the Mini Mental State Exam (3MS) and an occupational history questionnaire. The questionnaire included questions about exposures to various classes of pesticides and the regularity and duration of use. Participants were re-examined approximately every three years for up to 12 years of follow-up (mean 7.2 years, standard deviation 3.5). Mixed effects models were used to estimate trajectories of cognitive function over time according to categories of pesticide exposure and APOE ε4 status. There was a significant difference in baseline scores (p =0.0001) but not change over time between APOE ε4 negative participants who were exposed to pesticides versus those not exposed to pesticides (Table). Participants with one or more APOE ε4 allele(s) and no pesticide exposure scored lower (p =0.002) on their baseline 3MS and declined significantly faster over time (p =0.005) compared to unexposed participants who were APOE ε4 negative. Participants who were exposed to pesticides and had one or more APOE ε4 alleles had a statistically significant difference in baseline score (p =0.0001) and also declined significantly faster over time (p =0.001) compared to those with no exposure and no APOE ε4 alleles. Individuals with one or more APOE ε4 alleles who were exposed to pesticides declined significantly faster than those with no APOE ε4 alleles and no pesticide exposure. Although the difference in change over time is relatively small, effects over several years could be clinically significant. As pesticides have become so ubiquitous, further study is needed to determine the effect on cognition of non-occupational exposures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".