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Record W2161302159 · doi:10.1093/jnci/dju173

Core Symptom Measures in Cancer Clinical Trials

2014· letter· en· W2161302159 on OpenAlexaff
Carolyn Gotay

Bibliographic record

VenueJNCI Journal of the National Cancer Institute · 2014
Typeletter
Languageen
FieldMedicine
TopicRadiomics and Machine Learning in Medical Imaging
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsCancerCore (optical fiber)Clinical trialMedicinePsychologyComputer scienceInternal medicine

Abstract

fetched live from OpenAlex

Some of the most exciting recent advances in cancer research have come from learning more about how diverse a disease “cancer” actually is. For example, genomic analysis has identified at least 10 subtypes of breast cancer, with implications for varying therapeutic approaches ( 1 ). Against this backdrop, the set of four papers in the current issue of the Journal take a seemingly opposite approach: seeking commonality in symptom assessment across cancers, with the aim of identifying a core set of symptoms for use in clinical trials ( 2–5 ). The four papers have slightly different emphases, all focusing on identifying core symptoms in: different cancers ( 2 ), prostate cancer ( 3 ), head and neck cancer ( 4 ), and ovarian cancer ( 5 ). The authors comprise some of the most respected researchers in the quality of life (QoL) and cancer field, and their desire to promote assessment of cancer-related symptoms in clinical trials is laudable.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.097
metaresearch head score (Gemma)0.362
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: Methods · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.903
Threshold uncertainty score0.513

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0970.362
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0070.003
Bibliometrics0.0030.004
Science and technology studies0.0010.003
Scholarly communication0.0060.005
Open science0.0030.004
Research integrity0.0090.016
Insufficient payload (model declined to judge)0.0060.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.392
GPT teacher head0.527
Teacher spread0.136 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
DomainMethods
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2014
Admission routes1
Has abstractno

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